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KMID : 0359320170570020105
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Korean Journal of Veterinary Research
2017 Volume.57 No. 2 p.105 ~ p.111
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Comparative in vivo biodistributions of nanoparticles and polymers of 177lutetium-labeled hyaluronic acids in mice during 28 days
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Lin Chunmei
Jeong Ju-Yeon
Yon Jung-Min
Park Seul-Gi
Gwon Lee-Wha
Lee Jong-Geol
Baek In-Jeoung
Nahm Sang-Soep
Lee Beom-Jun
Yun Young-Won
Nam Sang-Yoon
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Abstract
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Hyaluronic acid (HA) has been investigated for biomedical and pharmaceutical applications. This study was conducted to determine the distributions of HA nanoparticles (NPs; size 350?400 nm) and larger HA polymers in mice at intervals after application. 177Lutetium (Lu)-labeled HA-NPs or HA polymers were intravenously injected (5 mg/ kg) into male ICR mice, and radioactivity levels in blood and target organs were measured from 0.25 h to 28 days post-injection. In blood, the radioactivities of HA-NPs and HA polymer peaked at 0.5 h after injection but were remarkably decreased at 2 h; subsequently, they maintained a constant level until 6 days post-injection. HA-NPs and HA polymers were observed in the liver, spleen, lung, kidney, and heart (in ascending order) but were seldom observed in other organs. After 3 days, both the HA-NP and HA polymer levels showed similar steady decreases in lung, kidney, and heart. However, in liver and spleen, the HA-NP levels tended to decrease gradually after 1 day and both were very low after 14 days, whereas the HA polymer level accumulated for 28 days. The results indicate that HA-NPs, with their faster clearance pattern, may act as a better drug delivery system than HA polymers, especially in the liver and spleen.
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KEYWORD
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drug delivery system, hyaluronic acid, in vivo biodistribution, nanoparticle, 177lutetium
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